Pyoderma Faciale is definitely stress-hormone related. It tends to affect only the face in women in their 20′s to 30′s and is characterized by large, very red painful lesions that occur mostly down the middle of the forehead, cheeks and chin. You can see the pattern in the photograph below – notice how the inflamed lesions are only in the center of her face. Her cheeks are completely clear. This condition can affect women who have never had acne in their life and then they have this horrible breakout right after a very stressful time in their life. Talk about a double whammy!!